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Vaccine protects ferrets against 3 H5N1 strains

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first_imgJun 13, 2006 (CIDRAP News) – An avian influenza vaccine made through reverse genetics produced an immune response not only to the target H5N1 virus strain but to two other H5N1 strains in a study in ferrets, according to a report published by the Journal of Infectious Diseases.The findings, according to the study’s authors and an accompanying editorial, signal that an H5N1 vaccine may be protective even when the vaccine strain does not precisely match the strain of H5N1 challenge virus. This bolsters the strategy of stockpiling such a vaccine to prepare for a pandemic.The study was done by a team from St. Jude Children’s Research Hospital in Memphis, with Elena A. Govorkova as first author. The investigators used reverse genetics to produce an inactivated, whole-virus vaccine that combined the hemagglutinin (HA) and neuraminidase genes of the H5N1 strain A/HK/203/03 with the remaining genes of a strain of H1N1 virus called A/PR/8/34.The researchers vaccinated groups of three or four ferrets with either a single dose (7 or 15 micrograms [mcg]) of HA with aluminum hydroxide adjuvant or two doses of HA (7 mcg each, 3 weeks apart) without adjuvant.The ferrets studied were healthy young adults that tested negative for H5N1 and H1N1 viruses, though 90% tested positive for H3N2 virus obtained through natural infection, according to the report. Four control ferrets received phosphate-buffered saline instead of vaccine.The researchers tested serum antibody responses after vaccination. The single-dose ferrets had a mean anti-HA titer of 1:107 and 1:120 for the 7-mcg and 15-mcg doses, respectively. The mean anti-HA titer for animals receiving two doses were 1:115 after one dose and 1:982 after two.Controls and ferrets that received the single dose of vaccine were inoculated intranasally 4 weeks later with the target subtype of H5N1 virus. Those receiving two doses were challenged 1 week after the booster dose.After viral challenge, all control ferrets exhibited fever and weight loss, while two had respiratory signs and two showed lethargy. Six days after viral challenge, controls had lost 4% to 12% of their weight. In contrast, 1 of 3 ferrets that received a single dose of 7 mcg of HA had an elevated body temperature and weight loss, but none of the other vaccinated animals had either.Ferrets that received a single 7-mcg dose of vaccine had significantly (P<.05) lower virus titers than did controls on day 3, and only 1 of 3 shed virus 5 days after viral challenge. Among those receiving a single 15-mcg dose, 2 of 3 animals were shedding virus on day 3, and none by day 5.The authors state, "All vaccinated ferrets were protected against systemic spread of homologous virus [the vaccine strain]," which was not detected in the lung, brain, or olfactory bulb. In addition, they said, all vaccine regimens effectively reduced replication of the target H5N1 virus subtype in the upper respiratory tract.When tested against different H5N1 strains, the vaccine also proved effective, according to the article. Separate groups of ferrets were tested against both the HK/156/97 and Vietnam/1203/04 strains of H5N1.The vaccine provided protection against the HK/156/97 subtype, although those receiving a single 7-mcg dose showed minor clinical signs. Also, greater protection was noted for ferrets receiving two doses of the vaccine. All four control ferrets showed signs of disease but survived.The vaccine similarly protected against the Vietnam/1203/04 subtype, which killed the three control animals. Again, the two-dose regimen provided the greatest benefit.The authors report, "Our findings confirmed that a two-dose regimen is preferable for vaccination of an immunologically naïve population against a novel H5N1 strain. The second dose of vaccine significantly increased serum antibody production and conferred complete protection against challenge with a high dose of the homologous H5N1 virus."They conclude, "The results of our study show that protection can be gained even when the vaccine strain does not match the challenge virus. . . . Therefore, the strategy of stockpiling pandemic vaccines for administration to groups at high risk offers promise. Reverse-genetics technology allows for the rapid generation of a broad spectrum of vaccine virus libraries."In an accompanying editorial, Alan W. Hampson, Msc, deputy director of the World Health Organization Collaborating Centre for Reference and Research on Influenza in Melbourne, Australia, concurs. "Possibly the greatest significance of Govorkova et al's study," he writes, "is the demonstration of a significant cross-strain protective effect even in the presence of minimal antibody levels. This, together with human serological data generated with an H5N3 vaccine, strengthens the argument for stockpiling vaccine prepared from currently available H5N1 vaccine strains."Govorkova EA, Webby RJ, Humberd J, et al. Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J Infect Dis 2006 Jul 15;194(2):159-67 [Full text]Hampson AW. Ferrets and the challenges of H5N1 vaccine formulation (editorial). J Infect Dis 2006 Jul 15;194(2):143-5 [Full text]last_img read more

Kennedale hosts opening night for IMCA Modified Red River Tour

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first_imgKENNEDALE, Texas – The inaugural IMCA Red River Modified Tour takes drivers in three divi­sions to six tracks in Texas and Oklahoma. Pre-entries are in hand from nearly 130 drivers from nine states.IMCA Modified features May 26 at Kennedale Speed­way Park, May 27 at Heart O’ Texas Speed­way, May 28 at 281 Speedway, May 30 at Devil’s Bowl Speed­way and May 31 at Grayson County Speedway all pay $1,000 to win. The final Fast Shafts All-Star Invitational ballot qualifying event of the week is June 1 at Southern Ok­lahoma Speedway, with a top prize of $1,500.IMCA Sunoco Stock Cars and Smiley’s Racing Prod­ucts Southern SportMods race for $500 to win and a mini­mum of $50 to start each night. All events are draw/redraw and will be broadcast by IMCA.TV.IMCA Speedway Motors Weekly Racing National, Ra­zor Chassis South Central and EQ Cylinder Heads South­ern Region, Texas State and special series points, but no track points will be awarded.Series champions will be crowned in each division; Modified and Stock Car champions become eligible to qual­ify for their respective race of champions during the up­coming IMCA Speedway Motors Su­per Nationals fueled by Casey’s.IMCA RaceSaver Sprint Cars are on May 26 and 27 pro­grams.Smiley’s Racing Products hosts an off-day lunch from 11 a.m.-1 p.m. on Tuesday, May 29 at its 103 Gross Road location in Mesquite. Tour drivers can visit the facil­ity and pick up any parts they need that day.Questions can be directed to Tour Director Selby Holder at 254-715-5742.IMCA Modified drivers pre-entered include Jeffrey Abbey, Comanche; Chase Allen, Midlothian; Drew Armstrong, Benton, Ark.; Rusty Belcher, Southmayd; Chris Bragg, Springtown; Chance Brown, Merkel; Mark Carrell, Redmond, Ore.; Robbie Daniels, Tom Bean; Cory Davis, Eunice, N.M.; Bo Day, Greenville; and Peter DeGrote, Granbury.Colin Deming, Hobbs, N.M.; J.P. Dowell, Killeen; Joe Duvall, Claremore, Okla.; Chris Elliott, Abilene; Tyler Frye, Belleville, Kan.; John Gober, Poolville; Jason Gomez, Princeton; Joe Gomez, Blue Ridge; David Goode Jr., Copperas Cove; William Gould, Calera, Okla.; and Kevin Green, Waco.Matt Guillaume, Haslet; Mike Hansen, Dickinson, N.D.; Brint Hartwick, Quitman, Ark.; Hardy Henderson, Harker Heights; Tyson Henson, Bonham; Simon Hernandez, Princeton; Garrett Higgins, New Waverly; Jason Hilliard, Cache, Okla.; Jeff Hoegh, New Caney; Danny Hogue, Abilene; and Brandon Hood, McGregor.Jason Hunter, Poolville; Allen Juelch, Durant, Okla.; Raymond King, Wylie; T.J. Lackey, Springtown; Matt Lynch, Cleveland; Christopher Luttmer, Saint Jo; Justin McCoy, Waxahachie; Josh McGaha, Abilene; William McGuire, Belton; David McKay, Van Alstyne; and Robert McKinney, Alvarado.Raymond McSpadden, Buda; Matt Martin, Alvarado; Chad Melton, Mineral Wells; Erik Miles, Haltom City; Talon Minten, Seguin; Clay Money, Penokee, Kan.; Mike Moore, Springtown; Chris Morris, Taylor; Justin Radcliff, China Spring; Shawn Ritter, Keystone, Iowa; and Nick Roberts, Des Moines, Iowa.Danny Rodgers, Midlothian; Shawn Sandegren, Montgomery; Brian Schultz, Casa Grande, Ariz.; Jesse Schwettmann, Tatum; Mark Shipman, Grandview; Cody Shoemaker, Decatur; Riley Simmons, Susanville, Calif.; Marvin Skinner, Mansfield; Ryan Slott, New Waverly; and Tyler Stevens, Searcy, Ark.Kevin Sustaire, Emory; Charlie Thieme, Fort Worth; Max Thomas, Quinlan; Dillon Tindall, La Grange; Danny Turner, Brenham; Eric Tomlinson, Waco; Rodney Twardeski, Huntsville; Kyle Whitworth, Leonard; Ryan Williams, Waxahachie; and Fred Wojtek, Blackwell.Pre-entered IMCA Sunoco Stock Car drivers are Westin Abbey, Comanche; Charlie Brown, Tuscola; Caleb Crenshaw, Fort Worth; A.J. Dancer, Red Rock; Markiss Harcrow, Killeen; Shannon Hartline, Ivanhoe; Brandon Hood, McGregor; Billy Lindsey, Merkel; Vernon Owens, Leander; Jason Riddle, Balch Springs; Justin Roberts, Sachse; Kevin Rogers, Emory; Andy Roller, Waco; Ranger Shipman, Grandview; Justin Wierenga, Killeen; Gary Williams, Bonham; and Shelby Williams, Bonham.Smiley’s Racing Products Southern SportMod pre-entries have been received from Tyler Bragg, Springtown; Nathan Buchanan, Tool; Devin Chambers, Marietta, Okla.; Chris Cogburn, Robinson; James Craig, Denison; Rowdy Day, Greenville; Riley Dickson, Whitesboro; Joseph Doremus, Springtown; Chris Florio, Copperas Cove; Taylor Florio, Copperas Cove; John Freeman, Runaway Bay; Donnie Hix, Sadler; Eric Kimbro, Lawton, Okla.; Sid Kiphen, Gatesville; Kasey Kuykendall, Howe; Robert McCutcheon, Prosper; and Kamera McDonald, Keller.And Tres Miller, Cache, Okla.; Kenneth Montgomery, Huntsville; Dustin Mooney, Forney; Greg Moran, Sherman; Justin Nabors, Kemp; Jacob Pirkle, Midlothian; Scot Raney, Sherman; Trevor Raney, Sherman; Danner Shipman, Grandview; Blaine Shives, Leonard; Brian Short, Denison; James Skinner, Burleson; Jake Upchurch, Grand Prairie; Chase Vineyard, Davis, Okla.; Wesley Warren, Fairfield; Rodney White, Ector; and Thomas Wyatt, Tom Bean.last_img read more

Dodgers rally for four runs in ninth inning to beat Mets

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first_img Dodgers’ Max Muncy trying to work his way out of slow start Newsroom GuidelinesNews TipsContact UsReport an Error PreviousActor Wayne Knight throws the ceremonial first pitch before a baseball game between the Los Angeles Dodgers and the New York Mets on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)The Dodgers’ Max Muncy #13 slides into home to score as Mets catcher Wilson Ramos #40 applies the tag in the bottom of the third inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Dodger starting pitcher Walker Buehler #21 during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG) SoundThe gallery will resume insecondsDodger starting pitcher Walker Buehler #21 during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Matt Beaty #45 is covered in beer and food after he went into the seats chasing a foul ball during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Dodger pitcher Walker Buehler #21 walks around the mound as the Mets’ Pete Alonso #20 heads for home plate after hitting a two run homer in the first inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Dodgers catcher Will Smith #16 watches as the Mets’ Pete Alonso #20 crosses crosses home plate after hitting a home run in the first inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Mets’ Pete Alonso #20 is congratulated by Michael Conforto #30 after Alonso hit a two run homer in the top of the first inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Justin Turner #10 fields a ground ball during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Justin Turner #10 throws to first base during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Mets starting pitcher Noah Syndergaard #34 during their MLB game against the Dodgers at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Dodger starting pitcher Walker Buehler #21 during their MLB game against the Mets at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Mets’ Todd Frazier #21 slides into home to score as Dodger catcher Will Smith #16 waits for the throw during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Mets’ Michael Conforto #30 goes to the wall on a Dodgers’ Matt Beaty #45 double in the bottom of the second inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Matt Beaty #45 slides into second base for a double as the Mets’ Amed Rosario #1 stops the throw in the bottom of the second inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Max Muncy #13 slides into home to score as Mets catcher Wilson Ramos #40 applies the tag in the bottom of the third inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)LOS ANGELES, CA – MAY 29: Corey Seager #5 of the Los Angeles Dodgers reacts after flying out with a runner on base in the third inning against the New York Mets at Dodger Stadium on May 29, 2019 in Los Angeles, California. (Photo by Jayne Kamin-Oncea/Getty Images)New York Mets’ Pete Alonso, left, celebrates with Dominic Smith after Alonso’s two-run home run against the Los Angeles Dodgers during the first inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers starting pitcher Walker Buehler throws to a New York Mets batter during the first inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets starting pitcher Noah Syndergaard watches a throw to a Los Angeles Dodgers batter during the second inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers starting pitcher Walker Buehler throws to a New York Mets batter during the first inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets starting pitcher Noah Syndergaard throws to a Los Angeles Dodgers batter during the second inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Pete Alonso (20) celebrates his two-run home run with teammates during the first inning of a baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers first baseman Matt Beaty leaps into the stands chasing a foul ball from New York Mets’ Amed Rosario during the first inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. Beaty did not make a catch on the play. (AP Photo/Marcio Jose Sanchez)New York Mets starting pitcher Noah Syndergaard throws to a Los Angeles Dodgers batter during the first inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers’ Matt Beaty (45) slides into second base with an RBI double next to New York Mets shortstop Amed Rosario during the second inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers’ Alex Verdugo, left, points to the team’s dugout after driving in a run with a double, next to New York Mets second baseman Adeiny Hechavarria during the second inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets third baseman Todd Frazier, left, talks to starting pitcher Noah Syndergaardduring the second inning of the team’s baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Pete Alonso hits a two-run home run against the Los Angeles Dodgers during the fifth inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Pete Alonso (20) is congratulated in the dugout after his two-run home run during the fifth inning of the team’s baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Pete Alonso, right, celebrates his two-run home run with Dominic Smith during the fifth inning of the team’s baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Pete Alonso (20) celebrates his two-run home run with Dominic Smith (22) and Michael Conforto (30) during the fifth inning of the team’s baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)New York Mets’ Dominic Smith (22) celebrates his solo home run with Amed Rosario (1) during the seventh inning of the team’s baseball game against the Los Angeles Dodgers on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers relief pitcher Julio Urias throws to a New York Mets batter during the seventh inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)The Dodgers’ Joc Pederson, right, celebrates with third base coach Dino Ebel as he rounds third base after hitting a solo home run to lead off the Dodgers’ four-run ninth-inning rally in their 9-8 victory over the Mets on Wednesday night at Dodger Stadium. Pederson homered on the ninth pitch of his at-bat against Edwin Diaz, who was pitching for the fourth time in five days. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers’ Cody Bellinger raises his arms in celebration after driving in a run with a double against the New York Mets during the ninth inning of a baseball game Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)The Dodgers’ Alex Verdugo #27 hits a bottom of the ninth walk off sacrifice fly to beat the Mets during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. The Dodgers beat the Mets 9-8. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Los Angeles Dodgers’ Alex Verdugo (27) watches as teammate Cody Bellinger, background left, scores the game-winning run on a sacrifice fly ball by Verdugo during the ninth inning of a baseball game against the New York Mets Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)The Dodgers’ Alex Verdugo #27is mobbed by teammates after he hit a bottom of the ninth walk off sacrifice fly to beat the Mets during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. The Dodgers beat the Mets 9-8. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Alex Verdugo (27) is mobbed by teammates after his sacrifice fly capped their four-run ninth-inning rally in a 9-8 victory over the Mets on Wednesday night at Dodger Stadium. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Joc Pederson #31 douses Alex Verdugo #27 after Verdugo hit a bottom of the ninth walk off sacrifice fly to beat the Mets during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. The Dodgers beat the Mets 9-8. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Justin Turner #10 covers Alex Verdugo #27 in powder after Verdugo hit a bottom of the ninth walk off sacrifice fly to beat the Mets during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. The Dodgers beat the Mets 9-8. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)The Dodgers’ Justin Turner #10 covers Alex Verdugo #27 in powder after Verdugo hit a bottom of the ninth walk off sacrifice fly to beat the Mets during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. The Dodgers beat the Mets 9-8. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)Actor Wayne Knight prepares to throw the ceremonial first pitch before a baseball game between the Los Angeles Dodgers and the New York Mets on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Actor Wayne Knight throws the ceremonial first pitch before a baseball game between the Los Angeles Dodgers and the New York Mets on Wednesday, May 29, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)The Dodgers’ Max Muncy #13 slides into home to score as Mets catcher Wilson Ramos #40 applies the tag in the bottom of the third inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)NextShow Caption1 of 44The Dodgers’ Max Muncy #13 slides into home to score as Mets catcher Wilson Ramos #40 applies the tag in the bottom of the third inning during their MLB game at Dodger Stadium in Los Angeles Wednesday, May 29, 2019. (Photo by Hans Gutknecht, Los Angeles Daily News/SCNG)ExpandLOS ANGELES — It was real. And it was spectacular.On a night when the Dodgers recognized a sitcom that was already in syndication when most of their starting lineup was starting grade school, the Dodgers scored four runs in the bottom of the ninth inning to come from behind and walk off with a 9-8 victory over the New York Mets on Wednesday night.All four runs came off Mets closer Edwin Diaz who had converted his previous 35 save opportunities (with the Mariners and Mets), allowing a total of four runs in those 35 games. But the Dodgers have now hung a total of five losses on three of the best relievers in the National League – Josh Hader, Kirby Yates and Diaz.“I don’t know, man,” Cody Bellinger said when asked how the Dodgers have done that. “I mean – we’re good.” How Dodgers pitcher Ross Stripling topped the baseball podcast empire Max Muncy made it back-to-back home runs and a one-run game.“Down three against Diaz is never easy obviously,” Bellinger said. “Once Joc hit it, we’re, ‘Alright, let’s just get guys on base now.’ Then Muncy hit one. And JT was in front of me so I was, ‘Aw, I’m going to have to hit with a guy on base probably because he’s good in these situations.’ I don’t know. We were just going up and down the lineup.”Justin Turner and Bellinger followed the back-to-back homers with back-to-back doubles to tie the score. After an intentional walk, Matt Beaty hit a soft grounder over the mound. Mets shortstop Amed Rosario fielded it near second base but couldn’t decide what to do with it. Everyone was safe, loading the bases for Verdugo.Like Pederson, he quickly fell behind 0-and-2.“First two pitches, I was swinging. I was going for it,” Verdugo said. “I went for it on the slider and was probably three feet from it. … So after that, I was like, that’s not me. Let’s tone it down.”His sacrifice fly drove in the winning run.“That was a good one,” Dodgers manager Dave Roberts said. “Our offense, those guys – they’re relentless. They’re relentless.”They had to be on a night when Walker Buehler was not at his best and the bullpen continued to spiral.Related Articles Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco center_img Cody Bellinger homer gives Dodgers their first walkoff win of season Buehler gave up a pair of two-run home runs to rookie Pete Alonso and five runs in five innings. That was the most he had allowed since April 11 in St. Louis (also the last time he failed to pitch past the fifth inning) and the most any Dodgers starter had given up since Rich Hill was also touched for five runs (only one earned) on April 28.The Mets hit two more home runs, back-to-back in the seventh inning when Julio Urias made his first appearance at Dodger Stadium since being reinstated following his arrest on suspicion of domestic battery.Those homers were part of the Dodgers bullpen’s latest poor performance, a three-run surrender that put the Dodgers down 8-3 at the seventh-inning stretch. It was the eighth time in the past nine games that Dodgers relievers have allowed a run (or more). In that stretch, the bullpen has allowed 26 runs in 26 2/3 innings.But a double by Pederson and a two-out RBI single by Turner produced a run in the seventh and convinced Roberts the game was salvageable.“You never want to concede,” Roberts said. “But at that time if he makes an out, I was going to take him out of the game and get him off his feet. But he gets the base hit there and once he did that and we’re in slam range, I just felt we’ve got to take our chances.” Dodgers hit seven home runs, sweep Colorado Rockies Alex Verdugo arrived at a similar conclusion when he was asked how the Dodgers were able to come back from a five-run deficit (8-3 in the seventh inning).“It just says, really – we’re nasty,” Verdugo said in the on-field interview, basking in the immediate afterglow of driving in the winning run and perhaps giddy on the combined fumes of a Gatorade bath and talcum powder drenching.“The boys can hit.”The Dodgers were one inning away from back-to-back losses to Jerry Seinfeld’s favorite team, which would have been their first back-to-back losses since they also lost two in a row in Chicago April 23-24.But Joc Pederson led off the ninth with a nine-pitch at-bat against Diaz, who was pitching for the fourth time in five days, the seventh time in the past 10. After falling behind 0-and-2, Pederson fouled off three pitches on the way to a full count then drove a slider over the wall in right-center field.last_img read more

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